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Phenotypes Associated with This Genotype
Genotype
MGI:3026744
Allelic
Composition
Efnb3tm1Henk/Efnb3tm1Henk
Genetic
Background
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1Henk mutation (0 available); any Efnb3 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants are unable to perform asymmeteric movements about 3 days after birth and instead show synchronous mirror movements, for example, during grooming, when scratching the head with one hindlimb, the other hindlimb moves simultanously with the working limb and scratches the air
• mirrored limb movement resulting in a hopping locomotion

nervous system
• corticospinal tract axons show an abnormal projection pattern in the spinal cord; collateral fibers branch into either the contralateral or ipsilateral side of the spinal cord gray matter
• axons aberrantly cross the midline boundary of the spinal cord and bilaterally innervate both contralateral and ipsilateral motor neuron populations


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory