Phenotypes Associated with This Genotype

Genotype
MGI:3026722

• Allelic Composition: inft8/inft8
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:89386 )

N • normal external genitalia, seminal vesicle size, testicular descent and seminiferous tubules

abnormal sperm flagellum morphology ( J:89386 )

♂ • sperm with either stumped, short tails or looped tails were present

oligozoospermia ( J:89386 )

♂ • severely reduced epididymal sperm count

globozoospermia ( J:89386 )

♂ • many sperm exhibited club-shaped heads

decreased sperm progressive motility ( J:89386 )

♂ • absence of forwardly progressive motile sperm

arrest of spermatogenesis ( J:85113 , J:89386 )

♂ (J:85113)

♂ • spermatogenic arrest at stage X, with spermatids in step 10 of spermiogenesis; apoptotic nuclei were noted in spermatids and in the tubule lumen (J:89386)

male infertility ( J:85113 )

♂

cellular

abnormal sperm flagellum morphology ( J:89386 )

♂ • sperm with either stumped, short tails or looped tails were present

oligozoospermia ( J:89386 )

♂ • severely reduced epididymal sperm count

globozoospermia ( J:89386 )

♂ • many sperm exhibited club-shaped heads

decreased sperm progressive motility ( J:89386 )

♂ • absence of forwardly progressive motile sperm