Phenotypes Associated with This Genotype

Genotype
MGI:3026718

• Allelic Composition: inft4/inft4
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:89386 )

N • normal external genitalia, seminal vesicle size, testicular descent and seminiferous tubules

short sperm flagellum ( J:89386 )

♂ • sperm with stumped, short tails were present

oligozoospermia ( J:89386 )

♂ • severely reduced epididymal sperm count, resulting in decreased testis weight

globozoospermia ( J:89386 )

♂ • many sperm exhibited club-shaped heads

decreased sperm progressive motility ( J:89386 )

♂ • absence of forwardly progressive motile sperm

arrest of spermatogenesis ( J:85113 , J:89386 )

♂ • block of spermatogenesis at the late differentiating spermatids stage (J:85113)

♂ • spermatogenic arrest at stage VII, with spermatids in step 8 of spermiogenesis; apoptotic nuclei were noted in spermatids and in the tubule lumen (J:89386)

male infertility ( J:85113 )

♂

cellular

short sperm flagellum ( J:89386 )

♂ • sperm with stumped, short tails were present

oligozoospermia ( J:89386 )

♂ • severely reduced epididymal sperm count, resulting in decreased testis weight

globozoospermia ( J:89386 )

♂ • many sperm exhibited club-shaped heads

decreased sperm progressive motility ( J:89386 )

♂ • absence of forwardly progressive motile sperm