Phenotypes Associated with This Genotype

Genotype
MGI:3026645

• Allelic Composition: Rorc^tm2Litt/Rorc^tm2Litt
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased thymocyte apoptosis ( J:87395 )

• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours

decreased double-negative T cell number ( J:91566 )

• numbers of intestinal alpha beta T cells including CD4^-CD8^- cells are significantly reduced

decreased double-positive T cell number ( J:87395 )

• fewer double-positive T cells (30-50% that of wild-type)

decreased NK cell number ( J:142654 )

• the percentage and absolute numbers of the Ncr(NKp46)⁺CD127⁺NK1.1^- subset of intestinal natural killer cells is strongly decreased compared to controls

• however, the number of NK1.1⁺ subset of intestinal natural killer cells is normal

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:91566 )

• numbers of intestinal alpha beta T cells including CD4⁺ cells are significantly reduced

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:91566 )

• numbers of intestinal alpha beta T cells including CD8alpha-beta⁺ and CD8alpha-alpha⁺ cells are significantly reduced

immune system

increased thymocyte apoptosis ( J:87395 )

• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours

decreased double-negative T cell number ( J:91566 )

• numbers of intestinal alpha beta T cells including CD4^-CD8^- cells are significantly reduced

decreased double-positive T cell number ( J:87395 )

• fewer double-positive T cells (30-50% that of wild-type)

decreased NK cell number ( J:142654 )

• the percentage and absolute numbers of the Ncr(NKp46)⁺CD127⁺NK1.1^- subset of intestinal natural killer cells is strongly decreased compared to controls

• however, the number of NK1.1⁺ subset of intestinal natural killer cells is normal

abnormal CD4-positive, alpha-beta intraepithelial T cell morphology ( J:91566 )

• numbers of intestinal alpha beta T cells including CD4⁺ cells are significantly reduced

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:91566 )

• numbers of intestinal alpha beta T cells including CD8alpha-beta⁺ and CD8alpha-alpha⁺ cells are significantly reduced

abnormal lymph organ development ( J:87395 )

• absence of lymphoid tissue inducer (LTi) cells

abnormal gut-associated lymphoid tissue morphology ( J:87395 , J:91566 )

• absence of lymphoid tissue inducer (LTi) cells (J:87395)

• intestinal cryptopatches and isolated lymphoid follicles are absent (J:91566)

absent Peyer's patches ( J:87395 )

absent lymph nodes ( J:87395 )

• mice lack all lymph nodes

cellular

increased thymocyte apoptosis ( J:87395 )

• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours

endocrine/exocrine glands

increased thymocyte apoptosis ( J:87395 )

• isolated thymocytes undergo apoptosis in culture within 2-3 hours compared to controls that survive for more than 5 hours