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Phenotypes Associated with This Genotype
Genotype
MGI:2686964
Allelic
Composition
Nefmtm1Mvr/Nefmtm1Mvr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nefmtm1Mvr mutation (1 available); any Nefm mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite neurofilament abnormalities, average rate of neurofilament transport is not different from controls
• severe inhibition of axonal radial growth between 2 and 6 months of age in motor axons and sensory axons
• however, no change in the total number of axons is detected
• about a 2 fold increase in total microtubule number
• increase in neurofilament density and decrease in nearest neighbor distances in motor axons
• crossbridges between neurofilaments are mostly short with fewer fine long crossbridges present

cellular
• severe inhibition of axonal radial growth between 2 and 6 months of age in motor axons and sensory axons
• however, no change in the total number of axons is detected


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory