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Phenotypes Associated with This Genotype
Genotype
MGI:2686810
Allelic
Composition
Tg(Rho)1Wbae/0
Genetic
Background
involves: C57BL/6 * SJL
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype

Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

vision/eye
• progressive reduction of both rod and cone photoreceptors with age
• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
• reduction in thickness of the outer nuclear layer
• ERGs from dark-adapted mutants show a significant reduction in teh amplitudes of a and b waves at P30
• between P30 and P210, the a wave gradually decreases and the b wave is reduced to about 30% of normal

nervous system
• progressive reduction of both rod and cone photoreceptors with age
• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:12791


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory