Phenotypes Associated with This Genotype

Genotype
MGI:2684380

• Allelic Composition: Grhl3^ct/Grhl3^tm1Jane
• Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

spina bifida ( J:86772 )

• the incidence of spina bifida in these embryos was higher than reported for ct homozygotes (31% vs 12%, respectively)

• the extent of the spina bifida more closely resembled ct (lumbosacral spina bifida) than the null allele (thorocolumbosacral)

• 14% of the mice had tail flexion defects only

• 5% of mice with this genotype were normal

embryo

spina bifida ( J:86772 )

• the incidence of spina bifida in these embryos was higher than reported for ct homozygotes (31% vs 12%, respectively)

• the extent of the spina bifida more closely resembled ct (lumbosacral spina bifida) than the null allele (thorocolumbosacral)

• 14% of the mice had tail flexion defects only

• 5% of mice with this genotype were normal