About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2683647
Allelic
Composition
Icostm1Flv/Icostm1Flv
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (2 available); any Icos mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T lymphocyte development normal in the thymus (J:87123)
• T lymphocyte development normal in the thymus (J:87123)
• production of IgE reduced (J:87123)
• production of IgE reduced (J:87123)
• reduction of IgG1 levels (J:87123)
• reduction of IgG1 levels (J:87123)
• defect indicated by low Il-4 levels and low IgG1 and IgE levels (J:87123)
• Th2 differentiation normal but function disrupted (J:87123)
• defect indicated by low Il-4 levels and low IgG1 and IgE levels (J:87123)
• Th2 differentiation normal but function disrupted (J:87123)
• Ifn-gamma levels were normal to slightly increased (J:87123)
• Ifn-gamma levels were normal to slightly increased (J:87123)
• Il-2 production defective (J:87123)
• Il-4 production very low (J:87123)
• Il-10 levels normal (J:87123)
• Il-13 levels reduced (J:87123)
• Il-2 production defective (J:87123)
• Il-4 production very low (J:87123)
• Il-10 levels normal (J:87123)
• Il-13 levels reduced (J:87123)
• lymph nodes were small in immunized mice (J:87123)
• about 1/2 as many cells/node as in wild-type mice (J:87123)
• lymph nodes were small in immunized mice (J:87123)
• about 1/2 as many cells/node as in wild-type mice (J:87123)
• greater succeptibility to experimental autoimmune encephalitis (J:87123)
• greater succeptibility to experimental autoimmune encephalitis (J:87123)

homeostasis/metabolism
• Ifn-gamma levels were normal to slightly increased (J:87123)
• Ifn-gamma levels were normal to slightly increased (J:87123)
• Il-2 production defective (J:87123)
• Il-4 production very low (J:87123)
• Il-10 levels normal (J:87123)
• Il-13 levels reduced (J:87123)
• Il-2 production defective (J:87123)
• Il-4 production very low (J:87123)
• Il-10 levels normal (J:87123)
• Il-13 levels reduced (J:87123)

hematopoietic system
• production of IgE reduced (J:87123)
• production of IgE reduced (J:87123)
• reduction of IgG1 levels (J:87123)
• reduction of IgG1 levels (J:87123)
• defect indicated by low Il-4 levels and low IgG1 and IgE levels (J:87123)
• Th2 differentiation normal but function disrupted (J:87123)
• defect indicated by low Il-4 levels and low IgG1 and IgE levels (J:87123)
• Th2 differentiation normal but function disrupted (J:87123)

Mouse Models of Human Disease
OMIM ID Ref(s)
Immunodeficiency, Common Variable, 1; CVID1 607594 J:87123


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory