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Phenotypes Associated with This Genotype
Genotype
MGI:2683647
Allelic
Composition
Icostm1Flv/Icostm1Flv
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icostm1Flv mutation (2 available); any Icos mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T lymphocyte development normal in the thymus
• production of IgE reduced
• reduction of IgG1 levels
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted
• Ifn-gamma levels were normal to slightly increased
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced
• lymph nodes were small in immunized mice
• about 1/2 as many cells/node as in wild-type mice
• greater succeptibility to experimental autoimmune encephalitis

homeostasis/metabolism
• Ifn-gamma levels were normal to slightly increased
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced

hematopoietic system
• production of IgE reduced
• reduction of IgG1 levels
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted

Mouse Models of Human Disease
OMIM ID Ref(s)
Immunodeficiency, Common Variable, 1; CVID1 607594 J:87123


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory