Mouse Genome Informatics
hm
    Icostm1Flv/Icostm1Flv
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
N
• T lymphocyte development normal in the thymus (J:87123)
• production of IgE reduced
• reduction of IgG1 levels
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted
• Ifn-gamma levels were normal to slightly increased
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced
• lymph nodes were small in immunized mice
• about 1/2 as many cells/node as in wild-type mice
• greater succeptibility to experimental autoimmune encephalitis

homeostasis/metabolism
• Ifn-gamma levels were normal to slightly increased
• Il-2 production defective
• Il-4 production very low
• Il-10 levels normal
• Il-13 levels reduced

hematopoietic system
• production of IgE reduced
• reduction of IgG1 levels
• defect indicated by low Il-4 levels and low IgG1 and IgE levels
• Th2 differentiation normal but function disrupted

Mouse Models of Human Disease
OMIM IDRef(s)
Immunodeficiency, Common Variable, 1; CVID1 607594 J:87123