Analysis Tools
pigmentation
belly spot
(
J:139244
)
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• ~10% of adult mice exhibit a white belly spot
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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• adults show excess epidermal pigmentation in the footpads, tail and ears
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• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
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• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
|
integument
belly spot
(
J:139244
)
|
• ~10% of adult mice exhibit a white belly spot
|
|
• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
|
• adults show excess epidermal pigmentation in the footpads, tail and ears
|
|
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
|
• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
|
growth/size/body
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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• mice show a ~10-15% reduction in birth weight relative to control mice
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• at P21, mice exhibit a significant reduction in body weight on both an inbred (C3HeB/HeJ) and a mixed genetic background
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hematopoietic system
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• mice exhibit a lower red blood cell (RBC) count on both an inbred (C3HeB/HeJ) and a mixed genetic background
• ~5% and ~10% reductions in RBC count are noted at 8 weeks and 20 weeks of age, respectively
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• mice show a ~50% reduction in reticulocyte count relative to control mice
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cellular
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• at 8 weeks of age, mice exhibit an increase in annexin V-positive bone marrow progenitor cells (lineage-cKit+) relative to control mice, indicating increased apoptosis
• however, bone marrow cytology is normal
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limbs/digits/tail
|
• excess pigment in a uniform and slanted stripe prominent over the volar pad at the base of the first digit; bluish-gray in color
(J:86685)
• increased footpad pigmentation is seen by 3 weeks of age and persists throughout adult life; pigment accumulates in the footpad epidermis
(J:139244)
• at P3, P10 and P30, Kitl (kit ligand) mRNA levels are significantly increased in the footpad epidermis relative to control mice
(J:139244)
• increased Trp53 staining is noted in the adult footpad epidermis relative to control mice
(J:139244)
|
|
• dark pigmentation of the tail
(J:81301)
• increased tail pigmentation is seen by 3 weeks of age and persists throughout adult life
(J:139244)
• pigment accumulates in the adult tail epidermis, whereas the dermis is unaffected
(J:139244)
|
craniofacial
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
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hearing/vestibular/ear
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• increased ear pigmentation is seen by 3 weeks of age and persists throughout adult life
|
