Phenotypes Associated with This Genotype

Genotype
MGI:2682060

• Allelic Composition: Cacna1h^tm1Kcam/Cacna1h^tm1Kcam
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system morphology ( J:86616 )

abnormal blood vessel morphology ( J:86616 )

• vessels in the heart have irregular spiral shapes

abnormal arteriole morphology ( J:86616 )

• exhibit constitutively constricted coronary arterioles

abnormal myocardial fiber morphology ( J:86616 )

• focal myocardial fibrosis

cardiac fibrosis ( J:86616 )

• exhibit progressive cardiac fibrosis starting at 10 weeks of age; hearts show large areas of fibrosis, necrosis, and lymphoctye infiltration

increased vasoconstriction ( J:86616 )

• vessels in the heart and coronary arterioles are constitutively contracted

• isolated coronary arteries show normal contractile responses but show reduced relaxation in response to acetylcholine and ntiroprusside

growth/size/body

decreased body size ( J:86616 )

• both males and females are smaller

nervous system

abnormal channel response ( J:86616 )

• the low voltage-activated calcium current (I_T is significantly diminished in dorsal root ganglia neurons, however no difference in the high voltage-activated calcium currents

muscle

abnormal myocardial fiber morphology ( J:86616 )

• focal myocardial fibrosis

increased vasoconstriction ( J:86616 )

• vessels in the heart and coronary arterioles are constitutively contracted

• isolated coronary arteries show normal contractile responses but show reduced relaxation in response to acetylcholine and ntiroprusside