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Phenotypes Associated with This Genotype
Genotype
MGI:2681992
Allelic
Composition
Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1(PRNP)Tkit mutation (1 available); any Prnp mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• less susceptible to MM2 type sporadic Creutzfeldt-Jakob disease (CJD) and variant CJD
• completely resistant to VV2 type sporadic CJD and dura-graft associated CJD with amyloid plaque
• highly susceptible to MM1 and MV1 type sporadic Creutzfeldt-Jakob disease (CJD), familial CJD (M232R), and dura-graft associated CJD without amyloid plaque

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Creutzfeldt-Jakob disease DOID:11949 OMIM:123400
J:86603


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory