Phenotypes Associated with This Genotype

Genotype
MGI:2681954

• Allelic Composition: S1pr1^tm1Rlp/S1pr1^tm2Rlp; Tg(Tek-cre)1Ywa/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Discontinuous smooth muscle cell coverage around the aorta in S1pr1^tm1Rlp/S1pr1^tm2Rlp Tg(Tek-cre)1Ywa/? mice

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:86450 )

• died before birth and by E14.5 no heartbeat is seen

cardiovascular system

abnormal cardiovascular system morphology ( J:86450 )

poor arterial differentiation ( J:86450 )

• vascular smooth muscle only on ventral side of aorta and vessels of the brain

• dorsal side of aorta incompletely covered with endothelium

abnormal aorta smooth muscle morphology ( J:106055 )

• discontinuous smooth muscle cell coverage is seen around the aorta

abnormal pericardial cavity morphology ( J:86450 )

• enlarged pericardial cavity at E12.5

abnormal cardiovascular system physiology ( J:86450 )

hemorrhage ( J:86450 )

• spots of bleeding on the body by E12.5

• by E13.5, massive bleeding was occuring

embryo

abnormal visceral yolk sac morphology ( J:86450 )

• by E12.5, yolk sac was edematous

• less blood than normal in vessels

limbs/digits/tail

abnormal limb morphology ( J:86450 )

• limbs underdeveloped and rounded at E12.5

muscle

abnormal aorta smooth muscle morphology ( J:106055 )

• discontinuous smooth muscle cell coverage is seen around the aorta