Mouse Genome Informatics
hm
    Fbln5tm1Krc/Fbln5tm1Krc
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• elongation and tortuosity of aorta
• loss of compliance
• variable severity
• right-sided heart failure, putatively due to severe emphysema and related pulmonary hypertension

craniofacial

respiratory system
• enlargement of distal airspaces observed 3 days after birth
• disruption of alveolar structure
• enlargement of distal airspaces observed 3 days after birth

integument
• skin hanging in folds

growth/size

Mouse Models of Human Disease
OMIM IDRef(s)
Cutis Laxa, Autosomal Recessive, Type IA; ARCL1A 219100 J:86753