About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2681434
Allelic
Composition
Prkntm1Shn/Prkntm1Shn
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkntm1Shn mutation (2 available); any Prkn mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• poorer performance in various measures of motor performance
• rotarod performance was normal

nervous system
• higher currents are required in striatal neurons to trigger synaptic response

homeostasis/metabolism
• higher than normal levels of dopamine in the striatum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116
J:86377


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory