About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2680727
Allelic
Composition
Il4ratm1Tch/Il4ratm1Tch
Genetic
Background
involves: 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Tch mutation (1 available); any Il4ra mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• impaired Il-4 induced CD4+ T cell proliferation
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia

respiratory system
• airway hyperresponsiveness to methacholine
• eosinophilic infiltration
• goblet cell hyperplasia
• with methacholine challenge

hematopoietic system
• decreased persistence of Th2 cells as indicated by Il-4, Il-5, and Il-13 production
• Th2 differentiation not impaired however
• levels are substantially higher than normal
• IgG1 and IgG2 levels are higher than normal in response to OVA stimulation
• impaired Il-4 induced CD4+ T cell proliferation

Mouse Models of Human Disease
OMIM ID Ref(s)
Asthma, Susceptibility to 600807 J:86215


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory