Mouse Genome Informatics
hm
    Foxn1nu/Foxn1nu
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• some mice die within 1 week of birth
• 55% mortality within 2 weeks
• 100% mortality by 25 weeks (J:5043)
• most die within a few weeks of weaning (J:30772)

endocrine/exocrine glands
(J:5043)

growth/size

liver/biliary system
• liver lobes were atrophied and covered with red scars
• variable degrees of severity, typically increasing with age at time of death

reproductive system
(J:5043)
• many sperm had coiled tails (J:5043)
• many females exhibited continuous dioestrus and metaoestrus phases (J:5043)
• severely reduced fertility (J:5043)

immune system
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
• virtual absence of small lymphocytes in the thymus dependent area and the post-capillary venules are often thin walled and empty

integument
• sparse hair growth around 5 weeks of age (J:5043)
• in some mice, cephalo-caudal migration of an irregular band of short sparse hair (J:5043)
• mice fail to grow a first coat of hair (J:30772)
• absent at birth
• older mice show repeated growth and loss of short and wavy vibrissae
• older mice show repeated growth and loss of short and wavy vibrissae
• reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin

behavior/neurological
• longer latency during the acquisition and reversal phases in a Morris water maze (J:90695)
• in the extinction phase spend more time in the training quadrant and are less able to recall data from the previous day's training (J:90695)
• replenishing mice with T cells from wild-type mice improves performance in a Morris water maze (J:90695)

cardiovascular system
• in the thymus dependent area of the lymph nodes the post-capillary venules are often thin walled and empty

hematopoietic system
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2

Mouse Models of Human Disease
OMIM IDRef(s)
DiGeorge Syndrome; DGS 188400 J:202300
T-Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 601705 J:11959