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Phenotypes Associated with This Genotype
Genotype
MGI:2679895
Allelic
Composition		 Ptentm1Ppp/Ptentm2Ppp
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Ppp mutation (0 available); any Pten mutation (81 available)
Ptentm2Ppp mutation (0 available); any Pten mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:86212 )
• incomplete penetrance
• 40% of males died in utero
• 75% of females died in utero

neoplasm
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

endocrine/exocrine glands
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

reproductive system
abnormal prostate gland morphology ( J:86212 )
• prostates were enlarged, irregular, and contained papillary projections 2 to 3 months after birth
• prostate growths detectable by 3 months of age
• growths surpassed the size of seminal vesicles by 6 to 8 months of age
prostate gland anterior lobe hyperplasia ( J:86212 )
• hypercellular with enlargements of the anterior lobes
prostate gland dorsolateral lobe hyperplasia ( J:86212 )
• hypercellular with enlargement of the dorsolateral lobes
prostate gland epithelial hyperplasia ( J:86212 )
• increased proliferation of epithelial cells
increased prostate gland tumor incidence ( J:86212 )
• 25% exhibited local invasion within the prostate at 6 months of age
• tumor cells disrupted the basement membrane and were observed growing into the surrounding stroma

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory