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Phenotypes Associated with This Genotype
Genotype
MGI:2679598
Allelic
Composition
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
FVB/N-Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)
• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)
• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)
• pulmonary metastases are observed in 94% of tumor-bearing female mice and 80% of tumor-bearing male mice (J:46460)

endocrine/exocrine glands
• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)
• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)
• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)
• inability to lactate from the time of the first pregnancy

integument
• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)
• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)
• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)
• inability to lactate from the time of the first pregnancy

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:46460


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory