Mouse Genome Informatics
tg
    Tg(MMTV-PyVT)634Mul/0
FVB/N-Tg(MMTV-PyVT)634Mul
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• pulmonary metastases are observed in 94% of tumor-bearing female mice and 80% of tumor-bearing male mice (J:46460)
• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)
• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)
• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)

endocrine/exocrine glands
• inability to lactate from the time of the first pregnancy (J:46460)

integument
• inability to lactate from the time of the first pregnancy (J:46460)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:46460