Phenotypes Associated with This Genotype

Genotype
MGI:2679598

• Allelic Composition: Tg(MMTV-PyVT)634Mul/0
• Genetic Background: FVB/N-Tg(MMTV-PyVT)634Mul/Nci

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:46460 , J:48285 , J:51424 , J:87544 )

• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)

• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)

• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)

increased metastatic potential ( J:46460 , J:48285 )

• pulmonary metastases are observed in 94% of tumor-bearing female mice and 80% of tumor-bearing male mice (J:46460)

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:46460 , J:48285 , J:51424 , J:87544 )

• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)

• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)

• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)

lactation failure ( J:46460 )

♀ • inability to lactate from the time of the first pregnancy

integument

increased mammary adenocarcinoma incidence ( J:46460 , J:48285 , J:51424 , J:87544 )

• all female carriers develop palpable mammary tumors by 5 weeks of age; male carriers also develop these tumors with a later age of onset (median 83 days of age) (J:46460)

• tumors are multifocal, highly fibrotic, and involved the entire mammary fat pad (J:46460)

• mammary tumors appear in males and females with 100% penetrance by 40 days of age (J:51424)

lactation failure ( J:46460 )

♀ • inability to lactate from the time of the first pregnancy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:46460