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Phenotypes Associated with This Genotype
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-a1tm1Ywk mutation (0 available); any Hba-a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• homozygotes display mild hemolytic anemia
• hemoglobin H (beta4) constitutes 15% of total hemoglobin, as shown by isoelectric focusing electrophoresis
• homozygotes display reduced hemoglobin levels relative to wild-type controls (13.20 +/- 0.69 g/dL versus 14.65 +/- 1.34 g/dL, respectively, n=5)
• homozygotes display a lower MCH than wild-type controls (12.15 +/- 0.50 pg versus 16.93 +/- 0.43 pg, respectively, n=5)
• homozygotes display a lower MCV than wild-type controls (45.05 +/- 1.22 fL versus 56.71 +/- 0.99 fL, respectively, n=5)
• homozygotes display a significantly higher reticulocyte percentage than wild-type controls (11.33 +/- 0.58 versus 2.58 +/- 0.84, respectively, n=3)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory