Mouse Genome Informatics
hm
    Hba-a1tm1Ywk/Hba-a1tm1Ywk
involves: 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• hemoglobin H (beta4) constitutes 15% of total hemoglobin, as shown by isoelectric focusing electrophoresis
• homozygotes display reduced hemoglobin levels relative to wild-type controls (13.20 +/- 0.69 g/dL versus 14.65 +/- 1.34 g/dL, respectively, n=5)
• homozygotes display a lower MCH than wild-type controls (12.15 +/- 0.50 pg versus 16.93 +/- 0.43 pg, respectively, n=5)
• homozygotes display a lower MCV than wild-type controls (45.05 +/- 1.22 fL versus 56.71 +/- 0.99 fL, respectively, n=5)
• homozygotes display a significantly higher reticulocyte percentage than wild-type controls (11.33 +/- 0.58 versus 2.58 +/- 0.84, respectively, n=3)
• homozygotes display mild hemolytic anemia

Mouse Models of Human Disease
OMIM IDRef(s)
Hemoglobin--Alpha Locus 1; HBA1 141800 J:35018