Phenotypes Associated with This Genotype

Genotype
MGI:2679509

• Allelic Composition: Hba-a1^tm1Ywk/Hba-a1^tm1Ywk
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hemolytic anemia ( J:35018 )

• homozygotes display mild hemolytic anemia

abnormal hemoglobin ( J:35018 )

• hemoglobin H (beta4) constitutes 15% of total hemoglobin, as shown by isoelectric focusing electrophoresis

decreased hemoglobin content ( J:35018 )

• homozygotes display reduced hemoglobin levels relative to wild-type controls (13.20 +/- 0.69 g/dL versus 14.65 +/- 1.34 g/dL, respectively, n=5)

decreased mean corpuscular hemoglobin ( J:35018 )

• homozygotes display a lower MCH than wild-type controls (12.15 +/- 0.50 pg versus 16.93 +/- 0.43 pg, respectively, n=5)

decreased mean corpuscular volume ( J:35018 )

• homozygotes display a lower MCV than wild-type controls (45.05 +/- 1.22 fL versus 56.71 +/- 0.99 fL, respectively, n=5)

reticulocytosis ( J:35018 )

• homozygotes display a significantly higher reticulocyte percentage than wild-type controls (11.33 +/- 0.58 versus 2.58 +/- 0.84, respectively, n=3)