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Phenotypes Associated with This Genotype
Genotype
MGI:2679502
Allelic
Composition
Eif2ak1tm1Jjch/Eif2ak1tm1Jjch
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak1tm1Jjch mutation (1 available); any Eif2ak1 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• heart enlargement of 50% as a result of iron deficiency

growth/size/body
• heart enlargement of 50% as a result of iron deficiency

hematopoietic system
• iron deficiency causes 10X enlargement of spleen
• red pulp of spleen is expanded
• erythroid precursors in spleen are increased
• RBC counts dropped severely
• erythroid precursors in bone marrow are increased
• RBC hemoglobin concentration increased
• increased insoluble precipitated globins with iron deficiency
• hemin unable to upregulate globin synthesis
• results in hyperchromia
• slight increase in RBC volume
• increased number of RBCs with Heinz bodies, by up to 80% with iron deficiency
• increase in larger sized polysomes
• global increase in protein synthesis in RBCs
• beta-globin mRNA levels unchanged so rate of translation initiation is increased
• increased sensitivity to erythroid stress

homeostasis/metabolism
• heme deficiency when fed an iron deficient diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory