Phenotypes Associated with This Genotype

Genotype
MGI:2679015

• Allelic Composition: Ikbkb^tm1.1Cgn/Ikbkb^tm1.1Cgn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85810 )

• die during embryogenesis

immune system

decreased interleukin-6 secretion ( J:79132 , J:85810 )

• TNF-mediated IL-6 production is reduced but not abolished in these embryonic cells (J:79132)

• production of IL-6 in response to IL-1, LPS, or TNF is reduced in MEFs compared to IKbkb^tm2.1Cgn MEFs (J:85810)

cellular

increased fibroblast apoptosis ( J:85810 )

• mouse embryonic fibroblasts (MEFs) are more sensitive to TNF-induced apoptosis than IKbkb^tm2.1Cgn MEFs