Analysis Tools
adipose tissue
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• greater amounts than wild-type controls
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endocrine/exocrine glands
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• some cells are devoid of secretory granules
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• some cells have reduced numbers of secretory granules
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• failed milk production with first, but not subsequent, litters
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growth/size/body
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• at 40 weeks of age the body fat of homozygous males is considerably higher than that of heterozygous males
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• proportionate skeletal size reduction
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• female homozygotes mated to intact or vasectomized males gain weight as a result of pregnancy or pseudopregnancy and have increased bone length in the tibia and femur, and increased length and width in the scapula and skull
(J:5710)
• both males and females have increased weight and bone growth as a result of pituitary grafts or a course of i.p. injections of ovine growth hormone
(J:5710)
• homozygous males display a linear increase of weight from 4 to 16 weeks of age; they do not have a peak growth rate at 5 weeks of age, which heterozygous males do, and out to 16 weeks of age homozygotes do not show a plateau in their body weight, which heterozygotes do by approximately 12 to 15 weeks of age
(J:81023)
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• reduced weight, beginning at 2 weeks of age
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homeostasis/metabolism
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• in the pituitary
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• in the pituitary
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• from 4 to 15 weeks of age homozygous males exhibit constant food conversion efficiency rather than the normal decay of food conversion efficiency seen in heterozygous controls
• homozygous males have a higher energy consumption per gram of body weight than do heterozygous controls
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reproductive system
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• only 50% sired first litters, only 50% of these sired second litters, third litters rare
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nervous system
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• some cells are devoid of secretory granules
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• some cells have reduced numbers of secretory granules
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behavior/neurological
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• although mature food intake is less than that of heterozygotes, it is commensurate with body weight with heterozygous males taking in an average 1.0 +/- .12 g/g body weight and homozygous males taking in an average of 1.2 +/- .23 g/g body weight
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• homozygotes have shorter non-rapid eye movement sleep episodes during the light period and have them slightly more frequently than do heterozygotes, homozygotes also have significantly decreased rapid eye movement sleep episode frequency during the light period although the duration of rapid eye movement sleep episodes is normal
• subcutaneous infusion of growth hormone increases the frequency of rapid eye movement sleep episodes during the light cycle to levels similar to those of heterozygous controls, although infusion of growth hormone does not correct the non-rapid eye movement sleep episodes
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skeleton
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• homozygous males have a lower bone mass than heterozygous males although the bone mass of both attains maturity at 12 to 15 weeks of age and has a maximum growth rate at 5 weeks
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• female homozygotes mated to intact or vasectomized males gain weight as a result of pregnancy or pseudopregnancy and have increased bone length in the tibia and femur, and increased length and width in the scapula and skull
• both males and females have increased weight and bone growth as a result of pituitary grafts or a course of i.p. injections of ovine growth hormone
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integument
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• failed milk production with first, but not subsequent, litters
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immune system
