Phenotypes for Sirt1 MGI:2677380 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sirt1^tm2Fwa/Sirt1^tm2Fwa
Genetic Background	involves: 129/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1^tm2Fwa mutation (0 available); any Sirt1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atrial septal defect ( J:85542 )

vision/eye

abnormal eye morphology ( J:85542 )

• eye morphogenesis is dramatically perturbed, with multiple retinal involutions at E18.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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