Phenotypes Associated with This Genotype

Genotype
MGI:2677319

• Allelic Composition: Ephb1^tm1Cmn/Ephb1^tm1Cmn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective

abnormal optic tract morphology ( J:85573 )

• marked reduction of the ipsilateral optic tract, by 43%, both at E17.5 and at birth

• axons from the ventrotemporal retina tend to cross the midline

• no obvious guidance errors in the optic nerve or tract other than ipsilateral reduction

abnormal axon morphology ( J:150550 )

• infra-pyramidal bundle (IPB) axons are longer than in wild-type mice

vision/eye

vision/eye phenotype ( J:85573 )

N • no intraretinal axon guidance errors observed in E17.5 embryos

cellular

abnormal axon pruning ( J:150550 )

• mossy fiber pruning is defective