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Phenotypes Associated with This Genotype
Genotype
MGI:2676317
Allelic
Composition
Ush1cdfcr-2J/Ush1cdfcr-2J
Genetic
Background
B6;129S4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ush1cdfcr-2J mutation (1 available); any Ush1c mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
• at 3 weeks of age, before hair cell degeneration was apparent, examination of of the organ of Corti revealed that stereocilia of the inner hair cells displayed a milder disorganization compared to the outer hair cells
• at 3 weeks of age, before hair cell degeneration was apparent, examination of of the organ of Corti revealed disorganization of the normally rigid and structured outer hair cell stereocilia
• 3 month old mice displayed a progressive loss of vestibular hair cells
• complete absence of acoustic brainstem response at 3 weeks of age
• mice are congenitally deaf

nervous system
• at 3 weeks of age, before hair cell degeneration was apparent, examination of of the organ of Corti revealed that stereocilia of the inner hair cells displayed a milder disorganization compared to the outer hair cells
• at 3 weeks of age, before hair cell degeneration was apparent, examination of of the organ of Corti revealed disorganization of the normally rigid and structured outer hair cell stereocilia
• 3 month old mice displayed a progressive loss of vestibular hair cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory