Phenotypes Associated with This Genotype

Genotype
MGI:2674947

• Allelic Composition: Gria2^tm1Rod/Gria2^tm1Rod; Gria3^tm1Zpj/Y
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:84336 )

♂ • normal at birth

♂ • increased mortality at 2 to 4 weeks of age

♂ • to about 20-30%

♂ • gradual increase of global abnormalities

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:84336 )

♂

tremors ( J:84336 )

♂ • severe tremors associated with movements

decreased locomotor activity ( J:84336 )

♂

nervous system

nervous system phenotype ( J:84336 )

♂N • no gross anatomic abnormalities seen in the CNS

♂N • synaptic structures in the CA1 region appear normal

abnormal synaptic plasticity ( J:84336 )

♂ • synaptic plasticity was greater

abnormal excitatory postsynaptic potential ( J:84336 )

♂ • field excitatory postsynaptic potential was reduced to 10-20% of wild-type and was significantly lower than in Gria2 mutant homozygotes

enhanced long-term potentiation ( J:84336 )

♂ • in the CA1 region

abnormal long-term depression ( J:84336 )

♂ • in the CA1 region LTD is enhanced

♂ • limited effect of D15 peptide in blocking LTD

growth/size/body

decreased body size ( J:84336 )

♂