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Phenotypes Associated with This Genotype
Genotype
MGI:2674328
Allelic
Composition
ArTfm/Y
Genetic
Background
involves: STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (3 available); any Ar mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

endocrine/exocrine glands
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background

hematopoietic system
• the percentage of TER119+ cells in the bone marrow is decreased
• however, the number of circulating TER119+ cells is not significantly different from controls
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• the percentage of TER119+ cells in the bone marrow is decreased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls

immune system
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory