Mouse Genome Informatics
ot
    ArTfm/Y
involves: STOCK EdaTa Atp7aMo-blo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background
• spermatogenesis does not proceed beyond meiosis prophase
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts

endocrine/exocrine glands
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background

hematopoietic system
• the percentage of TER119+ cells in the bone marrow is decreased
• however, the number of circulating TER119+ cells is not significantly different from controls
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls
• the number of MAC-1+ cells in the bone marrow is decreased
• the percentage of TER119+ cells in the bone marrow is decreased

immune system
• increase in the percentage and absolute number of B cell precursors
• however, the number of LPS responsive B cells is not increased
• the number of MAC-1+ cells in the bone marrow is decreased
• however, the number of circulating MAC-1+ cells is not significantly different from controls

Mouse Models of Human Disease
OMIM IDRef(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803