About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2674328
Allelic
Composition
ArTfm/Y
Genetic
Background
involves: STOCK EdaTa Atp7aMo-blo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ArTfm mutation (3 available); any Ar mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background (J:140803)
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background (J:140803)
• spermatogenesis does not proceed beyond meiosis prophase (J:140803)
• spermatogenesis does not proceed beyond meiosis prophase (J:140803)
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts (J:140803)
• male mice have female genitals, a blind ending vagina, inguinal testes, no scrotum and lack derivatives of the Wolffian ducts (J:140803)

endocrine/exocrine glands
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background (J:140803)
• Background Sensitivity: mice exhibit thickening and hyperplasia of peritubular myoid cells that is not as great as when the allele is present on a mixed NMRI and stock of origin background (J:140803)

hematopoietic system
• the percentage of TER119+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating TER119+ cells is not significantly different from controls (J:110923)
• the percentage of TER119+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating TER119+ cells is not significantly different from controls (J:110923)
• increase in the percentage and absolute number of B cell precursors (J:110923)
• however, the number of LPS responsive B cells is not increased (J:110923)
• increase in the percentage and absolute number of B cell precursors (J:110923)
• however, the number of LPS responsive B cells is not increased (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• the percentage of TER119+ cells in the bone marrow is decreased (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• the percentage of TER119+ cells in the bone marrow is decreased (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating MAC-1+ cells is not significantly different from controls (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating MAC-1+ cells is not significantly different from controls (J:110923)

immune system
• increase in the percentage and absolute number of B cell precursors (J:110923)
• however, the number of LPS responsive B cells is not increased (J:110923)
• increase in the percentage and absolute number of B cell precursors (J:110923)
• however, the number of LPS responsive B cells is not increased (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating MAC-1+ cells is not significantly different from controls (J:110923)
• the number of MAC-1+ cells in the bone marrow is decreased (J:110923)
• however, the number of circulating MAC-1+ cells is not significantly different from controls (J:110923)

Mouse Models of Human Disease
OMIM ID Ref(s)
Androgen Insensitivity Syndrome; AIS 300068 J:140803


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory