Phenotypes Associated with This Genotype

Genotype
MGI:2674150

• Allelic Composition: Ctnnb1^tm2Wbm/Ctnnb1^tm2Wbm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:60391 )

• no homozygous embryos found after E9.5

• normal numbers of homozygotes through E7.5

embryo

abnormal developmental patterning ( J:60391 )

abnormal gastrulation ( J:60391 )

abnormal germ layer development ( J:60391 )

• all embryonic cell layers present at E5.5

abnormal ectoderm development ( J:60391 )

• after E7.5 apoptosis became prominent in embryonic ectoderm

• beta-catenin required in embryonic ectoderm for development past egg cylinder stage

• no morp[hological abnormalities in embryonic and extraembryonic ectoderm

abnormal mesoderm development ( J:60391 )

failure to gastrulate ( J:60391 )

abnormal proximal-distal axis patterning ( J:60391 )

• lack of regionalization of the visceral endoderm

abnormal rostral-caudal axis patterning ( J:60391 )

• axis formation defects in endoderm

decreased embryo size ( J:60391 )

• growth from E5.5 to E7.5 represents a 2.5 fold reduction compared to wild-type

• at E6.5 mutant embryos more compact (shorter) than wild-type

absent mesoderm ( J:60391 )

• at E7.5

growth/size/body

decreased embryo size ( J:60391 )

• growth from E5.5 to E7.5 represents a 2.5 fold reduction compared to wild-type

• at E6.5 mutant embryos more compact (shorter) than wild-type