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Phenotypes Associated with This Genotype
Genotype
MGI:2673733
Allelic
Composition
Akt1tm1Nhy/Akt1tm1Nhy
Akt2tm1Rsg/Akt2tm1Rsg
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Nhy mutation (0 available); any Akt1 mutation (34 available)
Akt2tm1Rsg mutation (0 available); any Akt2 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• weights of newborns at birth are only about 50% normal
• weights of E18.5 embryos are only about 50% normal

homeostasis/metabolism
• adipocyte differentiation is retarded or does not occur

muscle
• individual muscle fibers are markedly reduced
• individual muscle cells are approximately 50% smaller than normal

respiratory system
• newborn homozygotes display labored breathing

skeleton
• ossification barely detectable at E14.5
• at E18.5 there was still extensive cranial cartillage as well as in the axial skeleton and limbs

integument
• most hair follicles do not develop beyond very early stage
• spinous layer particularly affected by skin thinning
• reduced proliferation of basal keratinocytes
• all layers of skin thinner but present


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory