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Phenotypes Associated with This Genotype
Genotype
MGI:2673311
Allelic
Composition		 Stat3tm1Desi/Stat3tm1Desi
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Desi mutation (1 available); any Stat3 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to endotoxin shock ( J:77307 )
• mutants challenged with bacterial lipopolysaccharide exhibit diminished recovery from endotoxic shock and exhibit severe acute tubular necrosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory