Phenotypes Associated with This Genotype

Genotype
MGI:2673172

• Allelic Composition: Hoxb4^tm2Bay/Hoxb4^tm2Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:4612 )

N • unlike Hoxb4^tm1Bay mutant mice, most or all homozygotes survive to adulthood

skeleton

skeleton phenotype ( J:4612 )

N • unlike Hoxb4^tm1Bay mutant mice, all homozygotes display a normal sternum

abnormal cervical axis morphology ( J:4612 )

• 20% of homozygotes show an extra ventral tubercle on the cervical axis (C2)

• 50% of homozygotes display broadening of the neural arch of C2, which is normally typical of C1

cervical vertebral transformation ( J:4612 )

• some homozygotes display a partial anterior homeotic transformation of the second cervical vertebra or axis (C2) to atlas (C1)

growth/size/body

growth/size/body region phenotype ( J:4612 )

N • unlike Hoxb4^tm1Bay mutant mice, adult homozygotes are normal in size

muscle

muscle phenotype ( J:4612 )

N • unlike Hoxb4^tm1Bay mutant mice, adult homozygotes display normal visceral morphology, with no detectable diaphragmatic hernias or eventrations