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Phenotypes Associated with This Genotype
Genotype
MGI:2673003
Allelic
Composition
Dtnbp1sdy/Dtnbp1sdy
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dtnbp1sdy mutation (1 available); any Dtnbp1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have diluted pigmentation in eyes (J:1958)
• mice have diluted pigmentation in eyes (J:1958)
• mice had fewer melanosomes in the choroids (J:85123)
• mice had fewer melanosomes in the choroids (J:85123)
• mice had fewer melanosomes in the retinal pigment epithelium (J:85123)
• mice had fewer melanosomes in the retinal pigment epithelium (J:85123)

behavior/neurological
N
• preliminary tests of mice, including prepulse inhibition tests identified no behavioral abnormalities (J:85123)
• preliminary tests of mice, including prepulse inhibition tests identified no behavioral abnormalities (J:85123)

hematopoietic system
• thrombin-stimulated platelets is depressed 2- and 3-fold (J:1958)
• thrombin-stimulated platelets is depressed 2- and 3-fold (J:1958)
• platelet dense granules are reduced in number (J:1958)
• platelet dense granules are reduced in number (J:1958)
• platelet serotonin levels are low although ATP dependent acidification activity of platelet organelles appears normal (J:85123)
• platelet serotonin levels are low although ATP dependent acidification activity of platelet organelles appears normal (J:85123)
• platelets have an abnormal uptake and flashing of mepacrine dye (J:85123)
• platelets have an abnormal uptake and flashing of mepacrine dye (J:85123)
• platelets have a reduced rate of collagen-induced aggregation (J:85123)
• platelets have a reduced rate of collagen-induced aggregation (J:85123)

muscle
N
• mice have no obvious muscle abnormalities (J:85123)
• mice have no obvious muscle abnormalities (J:85123)

renal/urinary system
• secretion of lysosomal enzymes from kidney is depressed 2- and 3-fold (J:1958)
• ceroid pigment is present in the kidney (J:1958)
• secretion of lysosomal enzymes from kidney is depressed 2- and 3-fold (J:1958)
• ceroid pigment is present in the kidney (J:1958)

vision/eye
• mice have diluted pigmentation in eyes (J:1958)
• mice have diluted pigmentation in eyes (J:1958)
• mice had fewer melanosomes in the retinal pigment epithelium (J:85123)
• mice had fewer melanosomes in the retinal pigment epithelium (J:85123)
• choroids melanosomes were generally smaller and irregular (J:85123)
• choroids melanosomes were generally smaller and irregular (J:85123)
• mice had fewer melanosomes in the choroids (J:85123)
• mice had fewer melanosomes in the choroids (J:85123)

homeostasis/metabolism
• platelet serotonin levels are low although ATP dependent acidification activity of platelet organelles appears normal (J:85123)
• platelet serotonin levels are low although ATP dependent acidification activity of platelet organelles appears normal (J:85123)
• mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time (J:1958)
• mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time mice have a prolonged bleeding time (J:1958)
• platelets have an abnormal uptake and flashing of mepacrine dye (J:85123)
• platelets have an abnormal uptake and flashing of mepacrine dye (J:85123)
• platelets have a reduced rate of collagen-induced aggregation (J:85123)
• platelets have a reduced rate of collagen-induced aggregation (J:85123)

integument


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory