Phenotypes Associated with This Genotype

Genotype
MGI:2672116

• Allelic Composition: Nog^tm1Amc/Nog^tm1Amc
• Genetic Background: either: 129/Sv or (involves: 129S1/Sv * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:47724 )

nervous system

abnormal neural tube morphology ( J:47724 )

• reduced in size

incomplete rostral neuropore closure ( J:47724 )

• Background Sensitivity: on a 129/Sv background the brain fails to close between the diencephalons and myelencephalon, sometimes remaining open all the way to the caudal limit

• Background Sensitivity: neural folds flatten at the 8-9 somite stage on the 129/Sv background

• Background Sensitivity: on a mixed background the brain closes

abnormal spinal cord morphology ( J:47724 )

• becomes kinked on both backgrounds

embryo

decreased embryo size ( J:47724 )

abnormal neural tube morphology ( J:47724 )

• reduced in size

incomplete rostral neuropore closure ( J:47724 )

• Background Sensitivity: on a 129/Sv background the brain fails to close between the diencephalons and myelencephalon, sometimes remaining open all the way to the caudal limit

• Background Sensitivity: neural folds flatten at the 8-9 somite stage on the 129/Sv background

• Background Sensitivity: on a mixed background the brain closes

abnormal notochord morphology ( J:47724 )

• occasional side branching and buckling at E10.5

abnormal somite development ( J:47724 )

abnormal rostral-caudal patterning of the somites ( J:47724 )

• abnormalities become increasingly severe in a caudal direction

decreased somite size ( J:47724 )

• reduced

skeleton

abnormal axial skeleton morphology ( J:47724 )

• shortened axis between fore and hind limbs

vision/eye

abnormal eye development ( J:47724 )

• perturbed

hearing/vestibular/ear

abnormal ear development ( J:47724 )

• perturbed

limbs/digits/tail

short limbs ( J:47724 )

• broad club shaped limbs

vestigial tail ( J:47724 )

• reduced at E12.5, absent later

growth/size/body

decreased embryo size ( J:47724 )

integument

abnormal hair follicle development ( J:59676 )

• significantly reduced numbers of hair follicles and fewer reach an advanced stage of morphogenesis than normal

• more apoptosis in hair placodes