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Phenotypes Associated with This Genotype
Genotype
MGI:2671158
Allelic
Composition
Tg(HD82Gln)81Gschi/0
Genetic
Background
involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HD82Gln)81Gschi mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lifespan is approximately 5-6 months

behavior/neurological
• endstage mice exhibit poor grooming
• impaired performance on the rotarod

nervous system
• degeneration of hypothalamic neurons
• nuclear inclusions are observed in the cortex and caudate by immunocytochemistry
• degeneration of neurons in various hypothalamic areas including the lateral hypothalamus, the ventromedial hypothalamic nucleus, and the and the paraventricular nuclei

growth/size/body
• in the last 4 weeks of life, mutants are much smaller than controls
• beginning at 2 months of age, mutants fail to gain weight
• weight loss is observed in the last 4-6 weeks before death

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:53797


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory