Mouse Genome Informatics
tg
    Tg(HD82Gln)81Gschi/0
involves: C3H/HeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• lifespan is approximately 5-6 months

behavior/neurological
• endstage mice exhibit poor grooming
• impaired performance on the rotarod

nervous system
• degeneration of hypothalamic neurons
• nuclear inclusions are observed in the cortex and caudate by immunocytochemistry
• degeneration of neurons in various hypothalamic areas including the lateral hypothalamus, the ventromedial hypothalamic nucleus, and the and the paraventricular nuclei

growth/size
• in the last 4 weeks of life, mutants are much smaller than controls
• beginning at 2 months of age, mutants fail to gain weight
• weight loss is observed in the last 4-6 weeks before death

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:53797