Analysis Tools
immune system
| N |
• normal dendritic cell migration and IL-12 production in response to a microbial antigen (STAg)
• normal Langerhans cell migration and APC function in response to contact sensitizer (oxazolone)
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• mice exhibit a reduction in the number of total monocytes compared with wild-type mice
• Gr1low monocytes are reduced 3-fold compared to in wild-type mice
• however, expression of Tg(S100A8-BCL2)1Lgs restores monocyte numbers
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• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice
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• following kidney ischemia and reperfusion
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homeostasis/metabolism
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• following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice
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vision/eye
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• following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice
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• subretinal microglial cells accumulate with age in the retina unlike in wild-type mice
• following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in heterozygous mice at 7 and 14 days post injury
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renal/urinary system
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• following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice
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nervous system
| N |
• normal neuronal-glial cross talk indicated by microglial response to peripheral nerve injury, 129P2/OlaHsd and C57BL/6 mixed genetic background
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cardiovascular system
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• following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice
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hematopoietic system
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• mice exhibit a reduction in the number of total monocytes compared with wild-type mice
• Gr1low monocytes are reduced 3-fold compared to in wild-type mice
• however, expression of Tg(S100A8-BCL2)1Lgs restores monocyte numbers
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• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice
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• following kidney ischemia and reperfusion
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cellular
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• following kidney ischemia and reperfusion
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