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Phenotypes Associated with This Genotype
Genotype
MGI:2669665
Allelic
Composition
Gjc2tm1(EGFP)Kwi/Gjc2tm1(EGFP)Kwi
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc2tm1(EGFP)Kwi mutation (1 available); any Gjc2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Disturbed myelin basic protein (MBP) expression accompanied by astrogliosis and microglial activation in juvenile Gjc2tm2.1Kwi/Gjc2tm2.1Kwi, Gjc2tm2.1Kwi/Gjc2+, and Gjc2tm1(EGFP)Kwi/Gjc2tm1(EGFP)Kwi mice

nervous system
• conspicuous astrogliosis in the cerebellar white matter at P10
• in the cerebellar white matter at P10 but not at P90
• decrease in the number of coupled cells per network in biocytin treated cells compared to wild-type cells
• at P10, fewer fine fibers are seen in the granular layer of the cerebellum and these fibers do not reach the Purkinje cell layer
• at P10, vacuoles are occasionally present in the white matter tract and myelin protein appears inhomogeneous
• conspicuous astrogliosis in the cerebellar white matter at P10
• vacuolated nerve fibers were reported, notably in the proximal segment of the optic nerve near where myelination starts
• observed in the proximal region of the optic nerve (J:83885)
• peripheral myelin was unaffected (J:83885)
• delayed myelin formation in the cerebellar white matter (J:174197)

hematopoietic system
• in the cerebellar white matter at P10 but not at P90

immune system
• in the cerebellar white matter at P10 but not at P90

cellular
• conspicuous astrogliosis in the cerebellar white matter at P10
• in the cerebellar white matter at P10 but not at P90
• decrease in the number of coupled cells per network in biocytin treated cells compared to wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory