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Phenotypes Associated with This Genotype
Genotype
MGI:2667791
Allelic
Composition
Mgat2tm1.1Jxm/Mgat2tm1.1Jxm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat2tm1.1Jxm mutation (0 available); any Mgat2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• absence of mature sperm in the seminiferous tubules

mortality/aging
• lethality within the first week, incomplete penetrance
• most mice that survived the first week of life lived to adulthood

behavior/neurological
• unable to swim and showed poor performance on the rotarod
• 80% reduction in grip strength
• exhibited by females on a background involving ICR

endocrine/exocrine glands

growth/size/body

hematopoietic system
• 80% reduction in the number of thymocytes
• severe reduction in the number of mature T cell precursors

homeostasis/metabolism
• observed in almost all aging mice
• observed in some aging mice

immune system
• 80% reduction in the number of thymocytes
• severe reduction in the number of mature T cell precursors

renal/urinary system
• observed in almost all aging mice
• observed in some aging mice

reproductive system
• absence of mature sperm in the seminiferous tubules
• presence of spermatocytes and absence of spermatids
• approximately 30% of females produced offspring

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital disorder of glycosylation type IIa DOID:0070253 OMIM:212066
J:80661


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory