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Phenotypes Associated with This Genotype
Genotype
MGI:2667352
Allelic
Composition
Twist1tm1Bhr/Twist1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Twist1tm1Bhr mutation (2 available); any Twist1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
N
• the overall shape of the neurocranium was normal
• poorly developed

limbs/digits/tail
• observed in 71% of mice

skeleton
• poorly developed
• cranial suture abnormalities were observed in 89% of mice
• 68% showed complete or partial craniosynostosis of the occipitointerparietal (OIP) suture
• 57% showed complete or partial craniosynostosis of the coronal suture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Saethre-Chotzen syndrome DOID:14768 OMIM:101400
J:79294


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory