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Phenotypes Associated with This Genotype
Genotype
MGI:2667203
Allelic
Composition
Fras1tm1Chpk/Fras1tm1Chpk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fras1tm1Chpk mutation (1 available); any Fras1 mutation (216 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: blisters become hemorrhagic and embryos die between E14.5 and E16.5 on a 129;C57BL/10 background
• Background Sensitivity: on a 129;NMR1 background, the phenotype is slightly milder allowing 50% of embryos to develop to term, half of which survive to adulthood and are fertile

limbs/digits/tail
• in various forms, observed in 90% of mice that survive to birth

renal/urinary system
• unilateral or bilateral renal agenesis, or dysgenesisi and hypoplasia

vision/eye
• mice that survive have permanent fusion of one or both eyelids

integument
• blisters become hemorrhagic and embryos die between E14.5 and E16.5
• subepidermal blistering in embryos observed in the head region around the eyes and the distal part of the limbs

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:83746


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory