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Phenotypes Associated with This Genotype
Genotype
MGI:2667203
Allelic
Composition
Fras1tm1Chpk/Fras1tm1Chpk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fras1tm1Chpk mutation (1 available); any Fras1 mutation (133 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: blisters become hemorrhagic and embryos die between E14.5 and E16.5 on a 129;C57BL/10 background
• Background Sensitivity: on a 129;NMR1 background, the phenotype is slightly milder allowing 50% of embryos to develop to term, half of which survive to adulthood and are fertile

limbs/digits/tail
• in various forms, observed in 90% of mice that survive to birth

renal/urinary system
• unilateral or bilateral renal agenesis, or dysgenesisi and hypoplasia

vision/eye
• mice that survive have permanent fusion of one or both eyelids

integument
• subepidermal blistering in embryos observed in the head region around the eyes and the distal part of the limbs
• blisters become hemorrhagic and embryos die between E14.5 and E16.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:83746


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory