Mouse Genome Informatics
STOCK EdaTa Atp7aMo-blo/+ +
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• indistinguishable from females
• XY mice had vaginas that remained closed in most mice, though some did open at 3 months of age
• most spermatocytes were arrested at meiotic prophase, though some were observed in metaphase
• testes were positioned amongst fat in the abdomen
• the epididymides were absent from XY mice
• the vas deferens were absent from XY mice
• XY mice possessed testes and female secondary structures including vagina and teats
• XY mice did not possess ovaries

• XY mice behaved like non-oestrus females, reduced aggression

digestive/alimentary system
• indistinguishable from females

endocrine/exocrine glands
• testes were positioned amongst fat in the abdomen

Mouse Models of Human Disease
Androgen Insensitivity Syndrome; AIS 300068 J:5173