Phenotypes Associated with This Genotype

Genotype
MGI:2665570

• Allelic Composition: Tg(Myh6-tTA)6Smbf/0; Tg(tetO-Vegfa)1Kesh/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:68214 )

• mesenchymal transformation and cellularization of the cardiac jelly are completely blocked in about half of E10.5 embryos

abnormal cardiac outflow tract development ( J:68214 )

• outflow tract development is impaired with cardiac jelly remaining empty by the time it is colonized with mesenchymal cells in controls

abnormal heart development ( J:68214 )

• exhibit abnormal cardiac development upon tetracycline treatment to induce early expression of Vegfa

abnormal endocardium morphology ( J:68214 )

• multi-layered endocardium