Phenotypes Associated with This Genotype

Genotype
MGI:2665508

• Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:31130 )

• die around E12.5

cardiovascular system

internal hemorrhage ( J:31130 )

• small foci of intraparenchymal hemorrhages within the central nervous system are seen in some E11.5 embryos

• E12.5 embryos exhibit extensive hemorrhages within the vertebral canal

• hemorrhages appear to originate within the ganglia of the cranial nerves

hemopericardium ( J:31130 )

• hemorrhages into the pericardial space, evident at E12.5

hemoperitoneum ( J:31130 )

• hemorrhages into peritoneal cavity, evident at E12.5

intraventricular hemorrhage ( J:31130 )

• E12.5 embryos exhibit extensive hemorrhages within the ventricle of the central nervous system

nervous system

intraventricular hemorrhage ( J:31130 )

• E12.5 embryos exhibit extensive hemorrhages within the ventricle of the central nervous system

embryo

abnormal embryonic hematopoiesis ( J:31130 )

• mutants lack fetal liver hematopoiesis; no erythroid, myeloid, or megakaryocyte elements are seen in livers at E11.5-E12.5

• progenitors for definitive hematopoiesis of either erythroid or myeloid lineages are absent from the yolk sac and liver

hematopoietic system

abnormal embryonic hematopoiesis ( J:31130 )

• mutants lack fetal liver hematopoiesis; no erythroid, myeloid, or megakaryocyte elements are seen in livers at E11.5-E12.5

• progenitors for definitive hematopoiesis of either erythroid or myeloid lineages are absent from the yolk sac and liver

liver/biliary system

pale liver ( J:31130 )

• slight pallor of the liver at E11.5

homeostasis/metabolism

hemopericardium ( J:31130 )

• hemorrhages into the pericardial space, evident at E12.5