Phenotypes Associated with This Genotype

Genotype
MGI:2664809

• Allelic Composition: H19^tm1Tilg/H19⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

increased placenta weight ( J:75054 )

• placentas are 54% heavier at E18.5 than in wild-type when the mutated allele is inherited maternally

growth/size/body

increased body weight ( J:25091 , J:75054 )

• heterozygotes inheriting the mutant allele from the mother exhibit an increase in body mass (28% difference from wild-type) (J:25091)

• heavier than controls at E18.5 when the mutated allele is inherited maternally (J:75054)

cellular

paternal imprinting ( J:25091 , J:75054 )

• defects are seen in heterozygotes that receive the mutant allele from the mother while those that receive the mutant allele from the father are normal (J:25091)

• when maternally inherited, the maternal H19 gene is repressed and the normally imprinted Igf2 and Ins-2 genes are expressed (J:25091)