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Phenotypes Associated with This Genotype
Genotype
MGI:2663891
Allelic
Composition
Mlh3tm1Lpkn/Mlh3tm1Lpkn
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh3tm1Lpkn mutation (1 available); any Mlh3 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• germ cell apoptosis following meiotic defects
• 7% of oocytes progressed to the 2 cell stage
• some spermatocytes arrest at pachytene
• most spermatocytes progressed to metaphase at which point they showed missegregation and aneuploidy

endocrine/exocrine glands

cellular


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory