Mouse Genome Informatics
hm
    Leprdb-Pas/Leprdb-Pas
DW/Pas
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• detected by 6 months of age
• males show a hypertrophic obesity whereas females display both an enlargement and an increase in number of fat cells
• total mitochondrial protein of brown fat is reduced
• visible in 3 to 4 week old mice (J:174584)
• mice become grossly obese, gaining weight until at least 16 months of age (J:174584)

adipose tissue
• mutant mice have twice as much interscapular fat mass compared with non-obese control mice
• detected by 6 months of age
• males show a hypertrophic obesity whereas females display both an enlargement and an increase in number of fat cells
• total mitochondrial protein of brown fat is reduced

behavior/neurological
• moderate increase in food intake compared with homozygous Leprob mice

homeostasis/metabolism
• blood glucoes levels are slightly elevated in males; females are normal
• detected by 6 months of age
• detected by 6 months of age

reproductive system
(J:174584)

hematopoietic system
• observed at 24 weeks of age

immune system
• observed at 24 weeks of age

liver/biliary system
• observed at 24 weeks of age

muscle
• observed at 24 weeks of age

limbs/digits/tail
• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice
• at 24 weeks of age tails of mutant mice are significantly shorter compared with those of normal mice

skeleton
• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:31095