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Phenotypes Associated with This Genotype
Genotype
MGI:2663736
Allelic
Composition
Leprdb-Pas/Leprdb-Pas
Genetic
Background
DW/Pas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprdb-Pas mutation (1 available); any Lepr mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• visible in 3 to 4 week old mice (J:174584)
• mice become grossly obese, gaining weight until at least 16 months of age (J:174584)

adipose tissue
• mutant mice have twice as much interscapular fat mass compared with non-obese control mice
• detected by 6 months of age
• males show a hypertrophic obesity whereas females display both an enlargement and an increase in number of fat cells
• total mitochondrial protein of brown fat is reduced

behavior/neurological
• moderate increase in food intake compared with homozygous Leprob mice

homeostasis/metabolism
• blood glucoes levels are slightly elevated in males; females are normal
• detected by 6 months of age
• detected by 6 months of age

reproductive system

hematopoietic system
• observed at 24 weeks of age

immune system
• observed at 24 weeks of age

liver/biliary system
• observed at 24 weeks of age

muscle
• observed at 24 weeks of age

limbs/digits/tail
• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice
• at 24 weeks of age tails of mutant mice are significantly shorter compared with those of normal mice

skeleton
• at 24 weeks of age mutant mice have significantly shortened femurs compared with those of normal mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:31095


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory