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Phenotypes Associated with This Genotype
Genotype
MGI:2663270
Allelic
Composition
cl/cl
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• many homozygotes die within 2 days after birth (J:294)
• at birth, the sex ratio is significantly skewed, roughly 2 females: 3 males, suggesting that pre-natal survival of female homozygotes is reduced (J:294)
• many homozygotes die within 2 days after birth (J:294)
• at birth, the sex ratio is significantly skewed, roughly 2 females: 3 males, suggesting that pre-natal survival of female homozygotes is reduced (J:294)
• 59% of homozygotes die before 14 days of age (J:294)
• many of these are lost by starvation due to inter-litter competition for milk (J:294)
• 59% of homozygotes die before 14 days of age (J:294)
• many of these are lost by starvation due to inter-litter competition for milk (J:294)
• 28% of homozygotes that survive the pre-weaning period die by 50 days of age (J:294)
• an additional 3% die by 100 days of age (J:294)
• only 9.5% survive over 100 days, with the oldest homozygote surviving to 297 days whereas its wild-type sib survived to 599 days (J:294)
• 28% of homozygotes that survive the pre-weaning period die by 50 days of age (J:294)
• an additional 3% die by 100 days of age (J:294)
• only 9.5% survive over 100 days, with the oldest homozygote surviving to 297 days whereas its wild-type sib survived to 599 days (J:294)

growth/size/body
• at birth and thereafter, homozygotes are slightly lighter in weight than wild-type littermates (J:294)
• at birth and thereafter, homozygotes are slightly lighter in weight than wild-type littermates (J:294)
• homozygotes display a reduced growth rate (J:294)
• homozygotes display a reduced growth rate (J:294)

limbs/digits/tail
• soft fleshy pads of tissue are noted on the weight-bearing areas of both fore- and hindlimbs (J:294)
• soft fleshy pads of tissue are noted on the weight-bearing areas of both fore- and hindlimbs (J:294)
• homozygotes display flaccid digits, even in the absence of clubfoot (J:294)
• digits are splayed apart or held together depending on the position and movement of the animal (J:294)
• homozygotes display flaccid digits, even in the absence of clubfoot (J:294)
• digits are splayed apart or held together depending on the position and movement of the animal (J:294)
• homozygotes show a significant increase in the incidence and extent of tarsal bone fusions relative to control mice (J:294)
• homozygotes show a significant increase in the incidence and extent of tarsal bone fusions relative to control mice (J:294)
• homozygotes display congenital dorsiflexed (simple calcaneun type) bilateral clubbing of the hindfeet (J:294)
• unilateral and bilateral clubbing of the forefeet is frequently observed (J:294)
• homozygotes display congenital dorsiflexed (simple calcaneun type) bilateral clubbing of the hindfeet (J:294)
• unilateral and bilateral clubbing of the forefeet is frequently observed (J:294)
• homozygotes exhibit frequent unilateral and bilateral clubbing of the forefeet (J:294)
• forelimbs appear abnormal even in the absence of clubfoot, as digits display the same flaccidity observed in clubbed feet (J:294)
• in addition, 8 of 157 homozygotes display variable dorsiflexion and eversion of the lower forelimbs both uni- and bilaterally (J:294)
• homozygotes exhibit frequent unilateral and bilateral clubbing of the forefeet (J:294)
• forelimbs appear abnormal even in the absence of clubfoot, as digits display the same flaccidity observed in clubbed feet (J:294)
• in addition, 8 of 157 homozygotes display variable dorsiflexion and eversion of the lower forelimbs both uni- and bilaterally (J:294)
• homozygotes exhibit congenital bilateral clubbing of the hindfeet (J:294)
• the hindlimbs are abnormally positioned, and the skin is frequently rubbed off on the weight-bearing region of the heel (J:294)
• homozygotes exhibit congenital bilateral clubbing of the hindfeet (J:294)
• the hindlimbs are abnormally positioned, and the skin is frequently rubbed off on the weight-bearing region of the heel (J:294)
• homozygotes show a significant increase in the incidence and extent of carpal bone fusions relative to control mice (J:294)
• homozygotes show a significant increase in the incidence and extent of carpal bone fusions relative to control mice (J:294)
• most homozygotes loop their tails forward over their back while walking (J:294)
• most homozygotes loop their tails forward over their back while walking (J:294)

skeleton
• homozygotes show a significant increase in the incidence and extent of tarsal bone fusions relative to control mice (J:294)
• homozygotes show a significant increase in the incidence and extent of tarsal bone fusions relative to control mice (J:294)
• homozygotes show a significant increase in the incidence and extent of carpal bone fusions relative to control mice (J:294)
• homozygotes show a significant increase in the incidence and extent of carpal bone fusions relative to control mice (J:294)

muscle
• homozygotes show a marked reduction of muscular tissues in the lower limbs, such that separation of individual muscles is almost unfeasible (J:294)
• however, muscles controlling palmar flexion are present, and muscles of the upper limbs appear normal (J:294)
• homozygotes show a marked reduction of muscular tissues in the lower limbs, such that separation of individual muscles is almost unfeasible (J:294)
• however, muscles controlling palmar flexion are present, and muscles of the upper limbs appear normal (J:294)

behavior/neurological
• when suspended by the tail, homozygotes are unable to grip a slender supporting object with their digits (J:294)
• loss of tenacity is, to some extent, compensated by the use of pincer movements of the limbs (J:294)
• when suspended by the tail, homozygotes are unable to grip a slender supporting object with their digits (J:294)
• loss of tenacity is, to some extent, compensated by the use of pincer movements of the limbs (J:294)
• homozygotes show an atypical position of the limbs and are unable to plantar flex their hindfeet (J:294)
• when homozygotes are held firmly, clubbed feet can be moved manually to the normal position; when released, the feet return to their original position (J:294)
• when clubbed hindfeet are forcibly plantar flexed, the skin on the dorsum of the foot is thrown up in longitudinal ridges; not observed in clubbed forefeet (J:294)
• homozygotes show an atypical position of the limbs and are unable to plantar flex their hindfeet (J:294)
• when homozygotes are held firmly, clubbed feet can be moved manually to the normal position; when released, the feet return to their original position (J:294)
• when clubbed hindfeet are forcibly plantar flexed, the skin on the dorsum of the foot is thrown up in longitudinal ridges; not observed in clubbed forefeet (J:294)

reproductive system
• the fertility of both sexes is lower than normal (J:294)
• the fertility of both sexes is lower than normal (J:294)
(J:294)
(J:294)
(J:294)
(J:294)

vision/eye
• eyes are often blocked by a viscous discharge (J:294)
• eyes are often blocked by a viscous discharge (J:294)
• eyelids are often gummed together by a viscous ocular discharge (J:294)
• the area between the eyelids is often reduced (J:294)
• eyelids are often gummed together by a viscous ocular discharge (J:294)
• the area between the eyelids is often reduced (J:294)
• the eyelids are occasionally denuded of hair (J:294)
• the eyelids are occasionally denuded of hair (J:294)

integument
• the eyelids are occasionally denuded of hair (J:294)
• the eyelids are occasionally denuded of hair (J:294)


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory