Mouse Genome Informatics
hm
    ckr/ckr
involves: C3H/HeRos * C57BL/10Ros
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• mice exhibit postural asymmetry
• mice exhibit general hyperactivity and hyperactivity in response to sensory stimuli
• however, treatment with clozapine or olanzapine reduces hyperactivity
• circling behavior is first observed at 1-2 weeks of age (J:10932)
• circling behavior is almost continuous throughout the night and in response to stress (e.g. hand clapping) during daytime (J:10932) (J:10932)
• both net rotations (defined as full turns in preferred direction minus full turns in non-preferred direction) and percentage preference (defined as full turns in preferred direction over total full turns x 100) are significantly increased during spontaneous nocturnal (16 hr) circling (J:10932)
• circling behavior is accompanied by a decrease in rearing, sniffling and grooming compared to wild-type mice (J:87399)
• circling is observed in an open field and in home cages (J:87399)
• however, treatment with clozapine or olanzapine reduces circling behavior (J:87399)
• mice preferentially circle to the left

nervous system
• by 1500% compared to in wild-type mice
• by 60% compared to in wild-type mice
• the dopamine D2 receptor binding sites in the striata of circling mice are increased by ~31% relative to normal heterozygous littermates (J:10932)
• myelinated axons are decreased 70% in the striatum compared to in wild-type mice (J:87399)
• however, the number of NOS and cholinergic interneurons in the striatum is normal (J:87399)
• fewer fine, individual myelinated fibers are present in the lateral quadrants of the caudate-putamen compared to in wild-type mice especially near the ventricular ependyma

hearing/vestibular/ear
N
• no hearing loss or inner ear defects are observed in spite of circling behavior (J:10932)
• no other behaviors characteristic of the shaker/waltzer syndrome are observed (J:10932)

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:87399