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Phenotypes Associated with This Genotype
Genotype
MGI:2663269
Allelic
Composition
ckr/ckr
Genetic
Background
involves: C3H/HeRos * C57BL/10Ros
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit postural asymmetry
• mice exhibit general hyperactivity and hyperactivity in response to sensory stimuli
• however, treatment with clozapine or olanzapine reduces hyperactivity
• circling behavior is first observed at 1-2 weeks of age (J:10932)
• circling behavior is almost continuous throughout the night and in response to stress (e.g. hand clapping) during daytime (J:10932) (J:10932)
• both net rotations (defined as full turns in preferred direction minus full turns in non-preferred direction) and percentage preference (defined as full turns in preferred direction over total full turns x 100) are significantly increased during spontaneous nocturnal (16 hr) circling (J:10932)
• circling behavior is accompanied by a decrease in rearing, sniffling and grooming compared to wild-type mice (J:87399)
• circling is observed in an open field and in home cages (J:87399)
• however, treatment with clozapine or olanzapine reduces circling behavior (J:87399)
• mice preferentially circle to the left

nervous system
• by 1500% compared to in wild-type mice
• by 60% compared to in wild-type mice
• the dopamine D2 receptor binding sites in the striata of circling mice are increased by ~31% relative to normal heterozygous littermates (J:10932)
• myelinated axons are decreased 70% in the striatum compared to in wild-type mice (J:87399)
• however, the number of NOS and cholinergic interneurons in the striatum is normal (J:87399)
• fewer fine, individual myelinated fibers are present in the lateral quadrants of the caudate-putamen compared to in wild-type mice especially near the ventricular ependyma

hearing/vestibular/ear
N
• no hearing loss or inner ear defects are observed in spite of circling behavior
• no other behaviors characteristic of the shaker/waltzer syndrome are observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:87399


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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory