Analysis Tools
cellular
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• decreased fertilization in vitro not due to a defect of egg and sperm fusion
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• reduced amount of sperm collected from the epididymis at 12 and 15 weeks of age
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mortality/aging
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• 8 of 78 pups died from unknown causes shortly after birth
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endocrine/exocrine glands
| N |
• normal serum levels of FSH and LH
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• abundance of preantral follicles
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• lack of antral follicles
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• a lack of antral follicles and an abundance of preantral follicles
• reduced response of following treatment with follicle stimulating hormone (FSH) and luteinizing hormone (LH)
• cumulus cells do not respond to either FSH or insulin-like growth factor
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• ovary weight reduced by approximately 50% at 10 weeks of age
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• size and weight reduced by approximately 50% at 10 weeks of age
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• reduced number of Leydig cells
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• testis weight reduced by approximately 50% at 10 weeks of age
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• size and weight reduced by approximately 50% at 10 weeks of age
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growth/size/body
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• body weight was 60 to 80% that of wild-type littermates between 2 to 6 weeks of age
• body weight was normal at birth and after 6 weeks of age
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• proportionate dwarfism between 2 and 6 weeks of age
• body size was normal at birth and after 6 weeks of age
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• occuring between 2 and 6 weeks of age
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immune system
| N |
• normal development and function of T, B, and mast cells
• normal cellularity in the bone marrow, thymus, spleen, and lymph nodes
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reproductive system
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• decreased fertilization in vitro not due to a defect of egg and sperm fusion
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• reduced amount of sperm collected from the epididymis at 12 and 15 weeks of age
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• abundance of preantral follicles
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• lack of antral follicles
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• a lack of antral follicles and an abundance of preantral follicles
• reduced response of following treatment with follicle stimulating hormone (FSH) and luteinizing hormone (LH)
• cumulus cells do not respond to either FSH or insulin-like growth factor
|
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• ovary weight reduced by approximately 50% at 10 weeks of age
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• size and weight reduced by approximately 50% at 10 weeks of age
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• reduced number of Leydig cells
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• testis weight reduced by approximately 50% at 10 weeks of age
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• size and weight reduced by approximately 50% at 10 weeks of age
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• immature uterine tubules
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• immature epididymis containing a reduced amount of a sperm
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• decrease in the number of ovulated oocytes
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• decreased response to superovulatory treatment
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• oocytes showed impaired function in IVF experiments
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• sperm showed impaired function in IVF experiments
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