Analysis Tools
growth/size/body
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• heterozygotes are fertile and apparently normal, though slightly smaller than wild-type mice
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hematopoietic system
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• at E14.5, the frequency of megakaryocyte CFU-MK precursors is slightly reduced in heterozygous fetal liver cultures, while the number of BFU-Es and CFU-Es remain similar to those in wild-type liver cultures
• however, neither a reduction of enucleated red blood cells nor an increased number of nucleated primitive erythrocytes is noted in vivo at E16.5
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