digestive/alimentary system
• loss of mucosal integrity and increased number of apoptotic cells after gut ischemia-reperfusion
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• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls
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immune system
• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented
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• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished
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• reduction in systemic inflammatory response following gut ischemia-reperfusion
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homeostasis/metabolism
• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls
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• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished
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• mutants show increased local injury but prevention of systemic inflammation following intestinal ischemia-reperfusion
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hematopoietic system
• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented
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