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Phenotypes Associated with This Genotype
Genotype
MGI:2662291
Allelic
Composition
Ikbkbtm2Mka/Ikbkbtm2.1Mka
Tg(Vil-cre)1Mka/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm2.1Mka mutation (0 available); any Ikbkb mutation (54 available)
Ikbkbtm2Mka mutation (0 available); any Ikbkb mutation (54 available)
Tg(Vil-cre)1Mka mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• loss of mucosal integrity and increased number of apoptotic cells after gut ischemia-reperfusion
• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls

immune system
• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented
• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished
• reduction in systemic inflammatory response following gut ischemia-reperfusion

homeostasis/metabolism
• mutants develop severe intestinal edematous change in response to gut ischemia-reperfusion compared to only mild edema in controls
• the increase in serum TNF-alpha that is observed in controls at 4 hours after gut ischemia-reperfusion is abolished
• mutants show increased local injury but prevention of systemic inflammation following intestinal ischemia-reperfusion

hematopoietic system
• neutrophil migration/recruitment into the lung after gut ischemia-reperfusion is reduced and lung edema is prevented


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory